After Raising $60M, Kura Oncology Renews Work on Shelved Cancer Drug

Xconomy San Diego — 

[Updated 3/12/15 9:55 am.] Even after the FDA refused to approve the anti-cancer drug tipifarnib in 2005, some experts could see a tantalizing glimmer of potential for patients with acute myeloid leukemia (AML) and other forms of cancer.

[Updated to add Kura’s presence in Cambridge, MA] Now the oral drug is getting a second chance at Kura Oncology, a new San Diego biopharmaceutical company led by Troy Wilson, a serial life sciences entrepreneur. Kura is springing onto the scene as a fully formed public company, after Wilson secured a $60 million investment accompanied by a reverse merger—an unusual route that enables Kura to publicly list its shares as quickly as possible. The company also has an office in Cambridge, MA, Wilson said.

Wilson wants to apply the concepts of “precision medicine” to determine if tipifarnib can be used to treat some people with certain types of AML and solid tumor cancers. The drug was shelved before advances in genomic sequencing, which are now being applied to help drug researchers identify the genetic traits of patients who respond well to certain drugs. “Tipifarnib was sort of the right drug at the wrong time,” Wilson said yesterday in a phone interview.

Wilson’s most notable success was San Diego’s Intellikine, which advanced a portfolio of anti-cancer drugs targeting the PI3 kinase pathway. Japan’s Takeda Pharmaceuticals acquired Intellikine at the end of 2011 in a deal valued at $310 million. Since then, Wilson has founded two other life sciences startups, Wellspring Biosciences and Avidity NanoMedicines.

Kura Oncology CEO Troy Wilson

Troy Wilson

The underlying concept of precision medicine, which has made national headlines this year thanks to a big push by the National Institutes of Health and President Obama, is to optimize healthcare—in the form of drugs or other measures—that is most effective for a patient based on his or her individual genetic traits. Kura intends to take advantage of advances in next-generation sequencing as well as emerging information about cancer genetics to identify the patients most likely to benefit from tipifarnib, Wilson said.

Kura is going to apply tipifarinib to AML, a fast-spreading cancer in which the bone marrow makes abnormal blood cells known as myeloblasts. In the United States, about 19,0000 new cases of AML are diagnosed each year, with the average patient facing an overall survival rate of 25 percent after five years.

Johnson & Johnson (NYSE: JNJ) discovered tipifarnib, which binds to a particular enzyme (farnesyl protein transferase), preventing it from activating Ras oncogenes and inhibiting the growth of certain types of cancer cells. The company tested the … Next Page »

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