Bio Roundup: Nationwide’s Rise, a Surgeon’s Quest, CRISPR USA & More

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a three-year partnership aiming to use the startup’s AI technology to discover new drugs to treat the liver disorder NASH. Gilead is paying South San Francisco-based Insitro $15 million up front.

—In other AI drug discovery news, Mountain View, CA-based twoXAR will work with South Korea’s SK Biopharmaceuticals to develop new treatments for lung cancer. No financial terms were disclosed.

Arrakis Therapeutics raised a $75 million Series B to build a pipeline of small molecule drugs that target RNA.

—Hatteras Venture Partners launched its sixth fund with an initial $94 million for seed and early-stage investments in life science startups.

—PureTech Health struck a research partnership with Boehringer Ingelheim to develop treatments for disorders associated with dysfunction of the connections between the brain, the immune system, and the gut.

—Nocion Therapeutics, of Cambridge, MA, started up with a $27 million Series A round to develop drugs meant to “silence” neurons that are involved in pain, inflammation, and other conditions, including chronic cough. Here’s more from STAT.

—Kintai Therapeutics emerged from stealth, revealing plans to develop small molecule drugs that tap into the biology of the gut to treat disease throughout the body.

—Fibrocell Science (NASDAQ: FCSC) landed $30 million up front in a collaboration with Castle Creek Pharmaceuticals to develop Fibrocell’s Phase 3-ready gene therapy for the rare, inherited skin disorder dystrophic epidermolysis bullosa.


—Hookipa Pharma (NASDAQ: HOOK) raised $84 million in an IPO that will support mid-stage tests of a drug for the prevention of cytomegalovirus infection.

—Turning Point Therapeutics (NASDAQ: TPTX) nabbed $166 million in an upsized IPO that will help it develop targeted cancer drugs.


—Xconomy profiled San Diego startup Amplyx, which is developing a treatment for infections of Candida auris, a fungus that has become increasingly resistant to other drugs.

—With US regulators set to potentially approve Novartis’s SMA gene therapy Zolgensma next month, the Swiss pharma presented new data at a medical meeting this week meant to support its use. Here’s more from Fierce Pharma.

—An experimental gene therapy licensed by Mustang Bio (NASDAQ: MBIO) from St. Jude Children’s Hospital cured eight infants with a form of a rare immune disorder known as X-linked severe combined immunodeficiency (The gene therapy Strimvelis, owned by Orchard Therapeutics, is approved for a different form of the disease). Bloomberg has more.

—Shares of WaVe Life Sciences (NASDAQ: WVE) fell roughly 24 percent after the company disclosed interim safety results from a Phase 1 study of an experimental RNA-based treatment, suvodirsen, for Duchenne muscular dystrophy. The problem: the side effects, seen in patients who got just one dose of the drug, were “disconcerting,” wrote Stifel analyst Paul Matteis in a research note. WaVe will start a late-stage study later this year.

—Johnson & Johnson (NYSE: JNJ) disclosed the details of a long-term study showing that its Type 2 diabetes drug canagliflozin (Invokana) helps lower the risk of kidney failure. Vantage has more on the results and their implications here.

—Clovis Oncology (NASDAQ: CLVS) scrapped a Phase 2 study of PARP inhibitor rucaparib (Rubraca) in bladder cancer after an early look at the data showed that the drug wasn’t effective.


—In a blog posted on Health Affairs, drug policy researchers Peter Bach and Mark Trusheim proposed abandoning the use of biosimilars to lower the prices of biologic drugs in favor of “post-exclusivity price regulations.” The post got the attention of ex-FDA commissioner Scott Gottlieb, who tweeted that it’s “far too early to throw in the towel on biosimilars,” which have struggled commercially.

—Amgen (NASDAQ: AMGN) said its osteoporosis drug romosozumab (Evenity) would cost $21,900 for a full, 12-month course of treatment. That price puts romosozumab on par with a rival drug sold by Radius Health (NASDAQ: RDUS).


—Xconomy posted a sneak peek at the agenda for our annual half-day life sciences event, “What’s Hot in Boston Biotech,” on May 21 at Bristol-Myers Squibb in Cambridge, MA. This year we’re featuring the gene therapy boom, the latest in Alzheimer’s disease research, the growing need for (and role of) diversity initiatives within the life sciences, community, and much more.


—Obsidian Therapeutics appointed Paul Wotton as CEO, succeeding part-time chief executive Michael Gilman. Gilman is now serving as the full-time CEO of Arrakis.

—Trudy Vanhove jumped from Jazz Pharmaceuticals (NASDAQ: JAZZ) to South San Francisco-based Surrozen to become chief medical officer.

Frank Vinluan contributed to this report.

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