So many companies want to "change the world," but how do you build something that makes a real difference? Advances in sectors like machine intelligence, connected devices, and healthcare are poised to transform human jobs and lives. But, especially in today’s political climate, technology and business leaders must also navigate—and find ways to influence—policy areas such as education and immigration to raise their odds of success.

Which ideas and companies will have the greatest impact on society? How are entrepreneurs and investors thinking about opportunities? And how can Boston’s talent pool and inventive culture be harnessed to solve the most important problems?