VC Activity in Boston Dipped in 2016; Here Are the Top 10 Deals & Exits

Venture investments in Boston-area companies dipped in 2016, amid a slowdown in VC activity nationwide that some observers are calling a “return to normalization” after an investing frenzy in the previous two years.

In the fourth quarter of 2016, Boston-area companies took in about $1.2 billion from investors via 132 deals. That was down from $2.1 billion invested in 134 deals in the previous quarter, and $1.4 billion invested in 155 deals in the fourth quarter of 2015. Those numbers come from Seattle-based PitchBook and the National Venture Capital Association (NVCA), which released its quarterly Venture Monitor report on Wednesday.

Overall in 2016, $6 billion was invested in Boston-area companies in 527 deals, according to PitchBook and NVCA data. That’s a notable drop-off from the $7.9 billion invested in 710 Boston-area deals in 2015.

Meanwhile, venture firms invested $12.7 billion in 1,736 companies nationwide during the fourth quarter last year. That’s a 20 percent drop from the $15.7 billion invested in the previous quarter, and a 12 percent decrease from the third quarter’s 1,965 deals, the Venture Monitor report found.

For 2016 overall, the report said venture firms invested more than $69.1 billion in 7,751 U.S. companies, which was the second-highest annual investment total in the past 11 years. The largest was in 2015, when VCs pumped nearly $78.9 billion into 9,742 companies.

Here are the top 10 funding deals for Boston-area companies in 2016, per PitchBook and the NVCA (including pre- and post-money valuation estimates from PitchBook):

1. Moderna Therapeutics, $474 million, pre-valuation: $4.3B, post-valuation: $4.7B.
2. DraftKings, $153 million round, no valuation estimate given.
3. Fuze, $112 million round, pre-valuation: $610.7M, post-valuation: $722.7M.
4. Onshape, $105 million round, pre-valuation: $695.9M, post-valuation: $800.9M.
5. Ginkgo Bioworks, $100 million, pre-valuation: $424.6M, post-valuation: $524.6M.
6. Indigo, $100 million round, no valuation estimate given.
7. Deciphera Pharmaceuticals, $90 million round, no valuation estimate given.
8. Iora Health, $75 million round, pre-valuation: $217.8M, post-valuation: $292.8M.
9. Carbon Black, $68.3 million round, pre-valuation: $540M, post-valuation: $608.3M.
10. Interactions, $67 million round, no valuation estimate given.

And here are the top 10 Boston-area exits, including price estimates from PitchBook (plus a bonus exit from greater New England):

1. Padlock Therapeutics, $600 million acquisition by Bristol-Myers Squibb
2. Tensha Therapeutics, $535 million acquisition by Roche
3. CloudLock, $293 million acquisition by Cisco
4. Intellia Therapeutics, $150 million IPO
5. Resilient Systems, $145 million acquisition by IBM Security
6. AbVitro, $125 million acquisition by Juno Therapeutics
7. Acacia Communications, $103.5 million IPO
8. Editas Medicine, $94.4 million IPO
9. Ra Pharmaceuticals, $91.6 million IPO
10. Runkeeper, $85 million acquisition by Asics
Bonus: New Hampshire-based Dyn, $650 million acquisition by Oracle

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