Epizyme Touts Early Data From Key Trial Of Blood Cancer Drug

Xconomy Boston — 

At a medical meeting today, Cambridge, MA-based Epizyme (NASDAQ: EPZM) is providing the latest look at the most significant trial in its nine-year history, a Phase 2 study of its cancer drug tazemetostat.

Epizyme for some time has touted tazemetostat as a potential treatment for a wide array of cancers that could also be safe enough to use over a long period of time. At the American Society of Hematology’s Lymphoma Biology meeting in Colorado today, Epizyme is releasing what CEO Robert Bazemore calls an “early snapshot” from a Phase 2 study in patients with different forms of the blood malignancy non-Hodgkin lymphoma.

How early? In essence, the trial is not even one-third complete. Epizyme has only enrolled 82 of the planned 270 patients, and only a handful of them have been treated for more than five months. Just one patient has been on the drug longer than eight months, making it irresponsible to draw conclusions about safety, efficacy, and how long the effective treatment might last. Epizyme officials did not draw conclusions, but they were effusive in their optimism: Chief medical officer Peter Ho told Xconomy that he is “extremely encouraged” so far. Another update will come later this year.

Epizyme is reporting today on the drug’s impact on the cancers of 47 patients, and its safety in 82 patients. These patients have different forms of NHL: either diffuse large-B cell lymphoma (DLBCL), the most common type, or follicular lymphoma (FL). They’ve also failed at least two prior treatments. Some carry mutations to an enzyme called EZH2—the target of Epizyme’s drug—and some don’t.

Patients with EZH2 mutations account for about 20 percent of DLBCL or FL cases. Epizyme hopes the EZH2 mutation carriers respond better to tazemetostat.

Epizyme has seen responses to tazemetostat in each of the four groups it’s reporting on today. Of the 47 patients evaluated for the drug’s effectiveness: nine have a “partial” response, meaning a shrinkage of their tumors; four have a “complete” response, or no trace of cancer in their blood; and 13 have stable disease, meaning their tumors haven’t significantly grown or shrunk.

“These numbers are nothing to jump up and down about,” says Robert Chen, a hematologist and assistant professor at the City of Hope National Medical Center in Duarte, CA, who isn’t involved with the tazemetostat trial. Chen is most impressed by one of the study groups, in which all three patients with FL and EZH2 mutations responded. Still, he cautions, “you might just be lucky getting three out of three responses. It’s too early… time will tell.”

Epizyme’s Ho, however, expects those numbers to improve over time based on a previous tazemetostat human trial, in which patient responses often took a while to kick in. Epizyme will need them to improve for the drug to make an impact on the field. “Unless the overall response rate is greater than 50 percent, [the drug] is not going to make it in the [NHL] space,” City of Hope’s Chen says.

Epizyme says among the 82 patients evaluated for safety, side effects been mild or moderate—like fatigue or loss of appetite—and “consistent” with what the company has seen in earlier testing. The most significant side effects, cases considered severe, were patients with low counts of white blood cells or platelets.

Epizyme saw some of this in earlier studies, and Ho says that some cases are likely related to the drug, and some the progression of their disease. It’s worth watching because Epizyme is trying to show that tazemetostat can be taken for months, perhaps years, without the debilitating effects of chemotherapy.

Chen, however, says there weren’t nearly enough instances of low platelet count (nine severe cases) or low white blood cell count (five) to be concerned, and even severe cases among NHL patients who have gone through multiple rounds of treatments are usually reversible. “This [looks like] a very tolerable drug,” he says of tazemetostat, adding that it looks much safer than the standard of care “R-CHOP” therapy, a mix of rituximab (Rituxan) and chemotherapy.

NHL encompasses many different blood cancers and is one of the most common cancer types, representing about 4 percent of all U.S. cancer cases, according to the American Cancer Society. More than 72,000 cases are expected to be diagnosed in the U.S. this year.

The forms of NHL are classified based on the appearance of the tumor cells. DLBCL cells are very large. FL cells grow in a circular pattern in the lymph nodes, according to the ACS.

Tazemetostat is what’s known as a targeted therapy, a small molecule drug designed to switch off the activity EZH2, which is implicated in a variety of cancers. As with all targeted cancer therapies, the idea is to hit the cancer cells and spare healthy tissue, unlike chemotherapy, which kills cancer and healthy cells alike.

Tazemetostat’s success is crucial to Epizyme. It’s one of only two drugs the company has in clinical testing. Epizyme splits the rights to the other drug, known as pinometostat, with Summit, NJ-based Celgene (NASDAQ: CELG). The company bought back rights to tazemetostat from Japan’s Eisai in March 2015, in part because of better results in a broader group of patients than the company had first envisioned. Often a bigger partner walks away from a drug because of disappointing results. But Bazemore, in a previous interview with Xconomy, said oncology wasn’t a top priority for Eisai at the time, and the drug “wasn’t moving as quickly and aggressively as we thought it could be.” A separate Phase 2 trial in solid tumors will produce data later this year.

Check out these stories for more on Epizyme and its plans for tazemetostat.