NeuroHealing Repurposes Drugs, Resulting in Potential New Remedies For CNS Disorders

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drugs approved to treat them. That would offer the company pricing power, which in turn could translate to a market of between $500,000 and $1 billion a year, Farber estimates.

NeuroHealing’s second product candidate required a combination of deep market research and resourcefulness. Farber and his colleagues wanted to develop a drug to address Parkinson’s, so they began asking physicians who treat the disease what the greatest unmet needs were among patients who suffer from it. Much to their surprise, one problem commonly cited was uncontrollable drooling—known by its scientific name as sialorrhea. “It’s a problem that patients are embarrassed to talk about,” Farber says. “We went to Parkinson’s support groups to talk to these patients, and the more research we did, the more we realized they really wanted a therapy to treat this.”

NeuroHealing found a potential remedy for drooling in a most unlikely place: the eye doctor’s office. The company’s experimental product, NH004, is a variation of tropicamide—a drug used for more than 50 years to dilate the pupils of patients prior to eye exams or surgeries. Tropicamide is an “anticholinergic agent,” meaning it blocks certain receptors in the nervous system. As an oral preparation, it blocks the acetylcholine receptors of the salivary glands, thereby providing a potential solution for drooling. NeuroHealing developed and patented a thin-strip technology, and transformed tropicamide into an oral drug that Parkinson’s patients can take to immediately dry out their mouths. The strip dissolves in the mouth over a period of 30 minutes to an hour. “We found a way to deliver it so it would work fast and not be intrusive,” Farber says.

NH004 has been tested in an initial study designed to determine the optimal dose. A second study is planned for this summer. The Michael J. Fox Foundation awarded NeuroHealing a grant to fund part of the trial program.

The Fox Foundation grant was part of what Farber calls an “unusual and creative funding history.” He won’t reveal how much NeuroHealing has raised all together, except to say the company has been bootstrapped with government grants, disease-foundation grants, personal investments from the founders, and some angel funding. Farber says the company is looking for corporate partners to help take its best clinical candidates through the development process.

Finding such a partner will be vital for advancing the company’s third drug, NH0D2, which it is developing to treat premature ejaculation. NH0D2 is a variation of modafinil (Provigil), a drug to treat sleepiness. “We recognized a side effect,” Farber says, namely an improvement in sexual function. NeuroHealing completed preclinical trials, but needs a deep-pocketed investor to take the drug further. Farber hopes the market potential will capture the attention of the pharma community. “We think it’s a $4 billion market opportunity,” he says.

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One response to “NeuroHealing Repurposes Drugs, Resulting in Potential New Remedies For CNS Disorders”

  1. Corinne L. Barca says:

    could this drug be crossed refrenced & fashioned for more broader spectrum of CNS diseases and/or disorders?
    For example multiple sclerosis- since it’s primary focus point is geared towards the connectivty between nerves.
    If so will this break through be able to show promise in other areas where the cause remains a blank study for various audio-immune diseases like lupus?
    Thank you for your continued concentration for the betterment of others.