Philanthropist John Flatley Starts Venture Group to Back New Cystic Fibrosis Treatments

Xconomy Boston — 

John Flatley, a real estate developer and philanthropist, has founded an investment group called Flatley Venture Capital to back life sciences startups with potential treatments for the genetic disease cystic fibrosis. Flatley, who has a close family member with the disease, told me he launched the venture group within the last few months.

Flatley Venture Capital, unlike a traditional VC firm, isn’t primarily focused on making profits on its investments, Flatley says. The venture outfit aims to provide between $200,000 and $2 million to support biotech startups that might not otherwise be able to afford to develop their technologies for the cystic fibrosis market, which consists of 30,000 patients in the U.S. and about 70,000 worldwide—numbers that pale in comparison to the cancer and heart disease markets. Flatley only expects to break even with his investments from the fund, he says.

Flatley, the son of the late Boston-area real estate mogul Thomas Flatley, has hired a Harvard University graduate named Alex Pickett as a senior analyst to evaluate deals for the venture group. While the group hasn’t made any investments yet, Flatley says “it’s going to be a substantial fund.” He says he is already considering backing two companies, which he declined to name.

This isn’t Flatley’s first foray to help advance cystic fibrosis treatments. He previously led the creation of a nonprofit laboratory, now called the Flatley Discovery Lab, in the Charlestown neighborhood of Boston. The nonprofit effort, quietly launched in 2008, has the mission of finding new drugs for cystic fibrosis, which causes the body to produce thick mucus that leads to chronic lung infections and poor absorption of nutrients. (The median life expectancy of someone with the disease was about 37 years in 2008).

When word got out last year that Flatley had started the research lab, formerly known as … Next Page »

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7 responses to “Philanthropist John Flatley Starts Venture Group to Back New Cystic Fibrosis Treatments”

  1. Felicia Weiner says:

    I have a 50 year-old daughter with this awful disease and all this time the CFF has been the most important component in the push to help find treatments and, I pray, a cure for cystic fibrosis. We Thank G-d for the John Flatley’s and the Bill Gates’ of the world who use their wealth for the benefit of others. Thank you so much for this effort.

  2. Angie Moran says:

    Yes thank you both for all you are doing I have a rare type of CF I also have a niece with CF age 19 and a Grandson of 3 who also has CF Thank you so much Bill Gates and John Flatley for all your help and hope for the future

  3. shelly says:

    Thank you so much, Mr Flatley, for your dedication to this cause. I am 50 yrs old and have CF. When given a life expectancy of 18 yrs, I never thought I would be living out my dreams as an adult with this disease. I have my own business and sell on HSN Television. When I was younger and they used to tell me that one day there would be a cure . . . I thought it was just words to make us all feel hopeful. Based on the advances made possible because of people like you, I now believe that I may live long enough to see CF stand for “Cure Found”, afterall. Sincerely, Shelly Maguire

  4. Random says:

    Not Genzyme, not even Boston.
    I am interested in CF drugs, though, and saw both John.John and MM as giving very similar, very bitter comments that were quite difficult to follow (even allowing for non native English). Neither had anything to do with the venture launch.
    BTW, I think the approach of VC funding rather than building it in house in a non-profit may make much more sense. It would also obviate the criticisms raised re the operations and team. Thoughts?

  5. mark ashwell says:

    OneWorldHealth ( is a good model for non-profit Pharma. CFRx is no where close to it. I am also interested in CF drugs, but you do not achieve success with random approaches; and half trained scientists as others wrote. The VC funding approach is for funding is a in-house lab which is funded by flately VC funds… They are operating since 2008 without success. As “S” put it that it is a flawed strategy by inexperienced scientists, who could not answer simple scientific questions. Keep your fingers crossed. I will do the same. Drug discovery is not an easy task otherwise CF drug should have been in the market. You cannot re-invent wheels using known failed methodologies for drug discovery.

  6. JD says:

    What is the progress? As Mark Ashwell puts it right, it is a waste of resources led by unqualified scientists.

  7. Jim says:

    Update in ventures ?